Neonatal isolation provokes hippocampal apoptosis and recognition memory impairment in rats

Neonatal isolation (NI) has detrimental consequences on the hippocampal neurons of rat neonates. It been reported to enhance neuronal cell death and impair memory behaviors. We conducted this study assess effects NI apoptosis recognition impairment in hippocampus One group male Wistar neonates exposed NI; reared with 1-hour neonatal for eight consecutive days (P2-P9). On other hand, control normally. Novel object test (NOR) used evaluate impairment. day 22 (P22), a TUNEL assay was done. NOR demonstrated that who experienced had long-term deficits (P<0.01). results showed increased number positive CA1, CA3, DG subfields (P<0.05, P<0.001, P<0.001). The present indicated exerted apoptotic effect induced neonate’s hippocampus.